?-Actinin (sarcomeric) Antibody
Mouse Monoclonal Antibody
Protein Family : Cytoskeleton Proteins Protein Family :
Pathway and Disease : Cell Motility, Cell Communication, Immune System, Infectious Diseases
Description : Alpha actinin (?-actinin) is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle ?-actinin isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Format : Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Applications : E, WB, IHC
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Alternate Names : Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1; ACTN1
Accession Number : Q07931
Clonality : SA-20
Isotype : Mouse IgG1
Antigen : Rabbit skeletal a-actinin.
Species Reactivity : H, M, R
Application Notes : E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500
Storage and Stability : Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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