Herbimycin A (Hsp90 Inbibitor)

Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2). It is effective on Src, Yes, Fps, Ros, Abl and ErbB oncogene products (1-3) and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C (4).

2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661.

3. Satoh T., et al.(1992) J.Biol.Chem. 267: 2537.

4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.