MagnaLink™ Streptavidin Magnetic Beads 2.8 µm

Highest biotin-binding capacity and exceptional uniformity deliver an ideal bead for high-throughput
MagnaLink™ Streptavidin Magnetic Beads offer the highest biotin-binding capacity on the market combined with exceptional uniformity. Higher binding translates to reduced bead mass required to immobilize a biotinylated sample and lower background noise from nonspecific binding, resulting in better signals and lower net costs.

MagnaLink™ Magnetic Bead—Exceptional Size Uniformity

MagnaLink™ Streptavidin Magnetic Beads are 2.8 micron-sized, super-paramagnetic, hydrophilic polymer–encapsulated (no exposed iron), monodispersed microspheres with a uniform size distribution and a fast (<2 min) magnetic response time. They are stable in colloidal form and in detergents. The key to high biotin binding is in the unique covalently crosslinked streptavidin, based on Solulink’s proprietary linking technology. The high surface area, when combined with our efficient linking chemistry, produces a consistent, ultra-high, biotin-binding bead. MagnaLink™ beads also demonstrate exceptional size uniformity of <5% CV, evident by scanning electron microscopy (SEM). These combined technologies make MagnaLink™ beads the ideal magnetic bead for high-throughput robotic applications.

Molecule          MagnaLink™ Binding Capacity   Competitor’s 1 µm Bead

                                                                         Binding

Free biotin                      >12 nmol/mg              650 – 900 pmol/mg

Biotinylated oligo (23-mer) >0.8 nmol/mg                     NA

Biotinylated IgG (3 biotins per IgG)112.6 µg/mg         5 – 10 µg/mg

Advantages

• Highest Biotin Binding – Supported by unique streptavidin crosslinking
• Fast (<2 min) Response Time – Saves time and accommodates viscous samples
• Exceptional Size Uniformity – Makes MagnaLink™ 2.8 µm beads ideal for high-throughput applications  

Applications

• Capture, immobilization, and separation of biotin-labeled biomolecules such as genomic DNA, RNA, PCR products, oligonucleotides, peptides, or antibodies. We recommend biotinylation with the ChromaLink™ Biotin Labeling Kit (Cat. No. B-9007-105K).
• High-throughput robotic applications where high biotin-binding loads must be removed or immobilized without the presence of an iron leachate.
• MagnaLink™ Streptavidin Magnetic Beads are ideally suited for generating single-stranded PCR templates that can dramatically increase hybridization efficiency to complementary probes by removal of the unbiotinylated competing PCR strand.

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