Neuregulin/Heregulin-1? (NRG-1?/HRG-1?), human recombinant protein

Short Summary : NRG-1?/HRG-1?, neurotrophin, expressed in E.Coli.

Category : Neurotrophins|Neuregulin

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Storage : Store at -20°C

Description : Neuregulin (NRG) is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells and plays an important role in heart structure and function through inducing cardiomyocyte differentiation. Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). HRG1-?1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases ErbB3/ErbB4, which induces ErbB3 and ErbB4 heterodimerization with ErbB2 and leads to tyrosine phosphorylation. HRG1-?1 is involved in up-regulation of expression and function of the autocrine motility-promoting factor (AMF).
Recombinant human Heregulin-?1 (HRG1-?1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-?1 (65 amino acid residues).

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