L-a-Hydroxyglutaric acid disodium salt

Short Summary : salt form of L-α-Hydroxyglutaric acid

Category : Metabolism|Dehydrogenase

Purity : 0.98

CAS Number : 63512-50-5

Formula : C5H6Na2O5

Molecular Weight : 192.08

SMILE : O=C([O-])[C@@H](O)CCC([O-])=O.[Na+].[Na+]

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : IC50: N/AL–Hydroxyglutaric acid disodium salt is a salt form of L–Hydroxyglutaric acid. L–Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, resulting in the metabolic disorder L–hydroxyglutaric aciduria.In vitro: It has been reported that L–Hydroxyglutaric acid disodium salt could be used as the collection buffer for increasing the recovery of hypoxia-inducible factor-1 , which was a marker of hypoxia in human tumors [1]. In another previous study, L–Hydroxyglutaric acid disodium salt was also used in the radiolabeled conversion assay to evaluate its effect on the TET family of methyl hydroxylases [2]. In vivo: In the 30-day-old rats, L–Hydroxyglutaric acid was found to be able to significantly increase chemiluminescence, PCF and TBA-RS measurements and decrease the TAR values in cerebellum markedly. In addition, the L–Hydroxyglutaric acid-induced increase of TBA-RS was significantly attenuated by melatonin and also by the combinations of ascorbic acid and soluble alpha-tocopherol (Trolox) and of superoxide dismutase plus catalase but not by the inhibitor of nitric oxide synthase Nomega-nitro-L-arginine methyl ester (L-NAME), , superoxide dismutase or creatine or catalase alone in either cerebral structure [3].Clinical trial: Up to now, L-a-Hydroxyglutaric acid disodium salt is still in the preclinical development stage.References:[1] Park SR,Kinders RJ,Khin S,et al. Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues. Anal Biochem.2014 Aug 15;459:1-11. [2] Evans B,Griner E. Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of -ketoglutarate-dependent dioxygenases. Elife.2015 Jul 31;4:e07420. [3] Latini A,Scussiato K,Rosa RB,Leipnitz G,Llesuy S,Bell-Klein A,Dutra-Filho CS,Wajner M. Induction of oxidative stress by L-2-hydroxyglutaric acid in rat brain. J Neurosci Res.2003 Oct 1;74(1):103-10.

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