Carfilzomib (PR-171)

Short Summary : Proteasome inhibitor,epoxomicin analog

Category : Ubiquitination/ Proteasome|Proteasome

Purity : 0.9976

CAS Number : 868540-17-4

Formula : C40H57N5O7

Molecular Weight : 719.91

SMILE : CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

Solubility : >36mg/mL in DMSO

Storage : Desiccate at -20°C

Description : An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.
References: 1. Guido Cavaletti, et al., Leukemia & Lymphoma (2010), 51(7), 1178-1187. 2. Girija Dasmahapatra, et al., Blood (2010), 115(22), 4478-4487.

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