Stattic

Short Summary : STAT3 inhibitor,small-molecule and potent

Category : JAK/STAT Signaling|STAT

Purity : 0.9958

CAS Number : 19983-44-9

Formula : C8H5NO4S

Molecular Weight : 211.19

SMILE : C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

Solubility : >10.6mg/mL in DMSO

Storage : Store at -20°C

Description : Stattic is a small molecule inhibitor of STAT3 with IC50 values of 2.562 0.409 M, 3.481 0.953 M, 2.282 0.423 M and 2.648 0.542 M, respectively, in UM-SCC-17B, OSC-19, Cal33 and UM-SCC-22B cell lines [1].Stattic is reported to selectively inhibit dimerization, activation and nuclear translocation of STAT3. It can also induce the apoptosis of STAT3-dependent breast cancer cell lines [2].The inhibition of STAT3 by Stattic results in decreased STAT3-mediated HIF-1 expression and subsequent radiosensitization of HNSCC cells. Inhibiting the STAT3 signaling pathway may represent an effective strategy in the treatment of HNSCC. The evidence of Stattic activity in vivo has also been found. Stattic pre-treatment sensitizes orthotopic xenograft HNSCC tumors to radiation, wich results in signi cantly reduced tumor growth, although this effect was not as dramatic as anticipated by the in vitro studies [1].References:[1] Makoto Adachi, Caixia Cui, Cristina T. Dodge, Mihir K. Bhayani, Stephen Y. Lai. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma. Oral Oncology. 2012 July(48):1220-1226.[2] Jochen Schust, Bianca Sperl, Angela Hollis, Thomas U. Mayer, and Thorsten Berg. Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization. Chemistry & Biology. 2006(13):1235-1242.

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