Y-27632 dihydrochloride

Short Summary : ROCK1 inhibitor

Category : TGF-β / Smad Signaling|ROCK

Purity : 0.98

CAS Number : 146986-50-7;129830-38-2

Formula : C14H21N3O.2HCl

Molecular Weight : 320.26

SMILE : CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N

Solubility : >16mg/mL in DMSO

Storage : Desiccate at RT

Description : Y-27632 dihydrochloride is a small-molecule inhibitor of Rho-associated protein kinase p160ROCK with the IC50 of 140 nM. Y-27632 suppresses the kinase activity of both ROCK-1 and ROCK-2 in vitro, and this compound inhibits the kinases by binding to the catalytic site of ROCK-1 and ROCK-2. Thus Y-27632 function on Rho-mediated stress fiber formation, the G1-S phase progression and cytokinesis.
References
1. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. T Ishizaki, M Uehata, I Tamechika, J Keel Molecular Pharmacology 2000
2. A ROCK inhibitor permits survival of dissociated human embryonic stem cells K Watanabe, M Ueno, D Kamiya, A Nishiyama. Nature Biotechnology. 2007

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