PD0325901

Short Summary : MEK inhibitor

Category : MAPK Signaling|MEK1/2

Purity : 0.9964

CAS Number : 391210-10-9

Formula : C16H14F3IN2O4

Molecular Weight : 482.19

SMILE : C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O

Solubility : >24.1mg/mL in DMSO

Storage : Store at -20°C

Description : PD0325901 is a specific inhibitor of mitogen-activated protein kinase MEK. PD0325901 is a small molecular with the formula of C16H14F3IN2O4 and Molecular Weight of 482. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, and MEK/ERK regulates cell proliferation, survival, and differentiation in response to extracellular signals. PD0325901 effectively reduces P-ERK levels and cell growth in vitro, and inhibits tumor growth in mouse model in vivo
References:1. Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901. J Leyton, G Smith, M Lees, M Peruma. Molecular cancer Therapeutics. 20082. Targeting mitogenactivated protein kinase kinase with the inhibitor PD0325901 decreases hepatocellular carcinoma growth in vitro and in mouse model. M Hennig, MT YipSchneider, S Wentz, H Wu. Hepatology. 2010

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