(R,R)-Formoterol

Short Summary : β2-selective adrenergic agonist

Category : GPCR/G protein|Adrenergic Receptor

Purity : 0.98

CAS Number : 67346-49-0

Formula : C19H24N2O4

Molecular Weight : 344.4

SMILE : CC(NCC(O)C1=CC(NC=O)=C(O)C=C1)CC2=CC=C(OC)C=C2

Solubility : 25℃: DMSO

Storage : Store at -20°C

Description : Description:
IC50 Value: N/A
Formoterol is a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could impart selective beneficial metabolic effects.
in vitro: Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1[1]. Formoterol (FM), but not SM, partially inhibited H(2) O(2) -induced PI3Kδ-dependent (PKB) phosphorylation. H(2) O(2) decreased SM-induced cAMP production in U937 cells, but did not significantly affect the response to FM [3].
in vivo: Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor γ coactivator 1α, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1β subcomplex subunit 8) [2]. Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 x 10(-10) and 4.7 x 10(-7) M, respectively [4].
Clinical trial: N/A

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