Acamprosate calcium

Short Summary : GABA receptor agonist and modulator of glutamatergic systems

Category : Membrane Transporter/Ion Channel|GABA Receptor

Purity : 0.9978

CAS Number : 77337-73-6

Formula : C10H20CaN2O8S2

Molecular Weight : 400.48

SMILE : CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2]

Solubility : Soluble to 100 mM in sterile water

Storage : Store at -20°C

Description : Acamprosate calcium is a synthetic drug for abstinence of patients with alcohol dependence [1].
Acamprosate administration can reduce alcohol intake. In rat model, oral acamprosate at dose of 50 to 400 mg/kg/day reduced voluntary oral ethanol consumption dose-dependently. However, the exact cellular target and mechanism of acamprosate is not clear. Acamprosate has a structure similar to that of GABA. It can specifically bind to GABAB receptors but not GABAA receptors. Besides that, acamprosate showed serotonergic properties. It increased 5-HT levels and the effects caused by 5-HT in rats exposed to ethanolvapour. Moreover, acamprosate was thought to have effects on inhibiting the excitatory activity of aminoacid and reducing Ca2+fluxes [1].
References:1. Wilde M I, Wagstaff A J. Acamprosate. Drugs, 1997, 53(6): 1038-1053.

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