Alvimopan

Short Summary : Mu-opioid receptors antagonist

Category : Endocrinology and Hormones|Opioid Receptor

Purity : 0.98

CAS Number : 156053-89-3

Formula : C25H32N2O4

Molecular Weight : 424.53

SMILE : C[C@@]1([H])CN(C[C@](/C(O)=N/CC(O)=O)([H])CC2=CC=CC=C2)CC[C@]1(C3=CC(O)=CC=C3)C

Solubility : DMSO

Storage : Store at -20°C

Description : Alvimopan(ADL 8-2698; Entereg; LY 246736) is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, Alvimopan(ADL 8-2698; Entereg; LY 246736) binds to mu-opioid receptors in the gut, thereby reversing opiod-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity.

Download datasheet