BAM7

Short Summary : BAX activator,direct and selective

Category : Apoptosis|Apoptosis Inducers

Purity : 0.98

CAS Number : 331244-89-4

Formula : C21H19N5O2S

Molecular Weight : 405.47

SMILE : CCOC1=CC=CC=C1NN=C2C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C

Solubility : Limited solubility

Storage : Store at -20°C

Description : BAM7 is a direct and selective activator of BAX with IC50 value of 3.3uM [1].In the competitive fluorescence polarization assay (FPA), BAM7 competes with FITCCBIM SAHB for BAX binding site(BH3) in a dose dependent manner. BAM7 shows no antiapoptotic or BAKC competitive binding interactions even at 50 M dosing, revealing a remarkable selectivity of BAM7 for BAX. The interaction between BAM7 and BAX at the very surface induces the characteristic structural changes that yield functional BAX oligomerization. In the in vitro assay, BAM7 induces BAX-dependent cell death but not the cells with BAK. BAM7 could be developed to a new generation of apoptotic modulators that directly activate BCL-2 family executioner proteins in cancerand other diseases driven by pathologic apoptotic blockades [1].References:[1] Evripidis Gavathiotis, Denis E Reyna, Joseph A Bellairs, Elizaveta S Leshchiner, and Loren D Walensky. Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 July ; 8(7): 639C645.

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