BMS-663068 Tris

Short Summary : HIV-1 attachment inhibitor

Category : Microbiology & Virology|gp120/CD4

Purity : 0.98

CAS Number : 864953-39-9

Formula : C29H37N8O11P

Molecular Weight : 704.62

SMILE : CC1=NN(C2=NC=C(OC)C3=C2N(COP(O)([O-])=O)C=C3C(C(N4CCN(C(C5=CC=CC=C5)=O)CC4)=O)=O)C=N1.OCC(CO)([NH3+])CO

Solubility : DMSO

Storage : Store at -20°C

Description : BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. BMS-663068 is a prodrug for BMS-626529 which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Administration of BMS-663068 for 8 days with or without ritonavir resulted in substantial declines in plasma HIV-1 RNA levels and was generally well tolerated. Longer-term clinical trials of BMS-663068 as part of combination antiretroviral therapy are warranted.

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