Cevimeline

Short Summary : Muscarinic receptor agonist

Category : Neuroscience|Muscarinic Receptor

Purity : 0.98

CAS Number : 107233-08-9

Formula : C10H17NOS

Molecular Weight : 199.32

SMILE : CC1OC2(CN3CCC2CC3)CS1

Solubility : Soluble in DMSO > 10 mM

Storage : Store at -20°C

Description : Cevimeline is a muscarinic receptor agonist especially on the M1 and M3 receptors. [1]
Cevimeline has been approved for use against symptoms of dry mouth by activating the M3 receptors of the parasympathetic nervous system. Cevimeline is effective and safe in improving symptoms of dry eye with 20 mg three times per day [2]. Cevimeline increased the intracellular Ca+ level in parotid gland acinar cells over 1 M and rat, enhanced the excitability via muscarinic receptors, thereby, cevimeline alleviates dry mouth symptoms by stimulating secretion by the salivary glands. Cevimeline has a longer duration of salivation[3]. Cevimeline plays a part in Alzheimers disease. Cevimeline decreased A (1C40) level in the cerebrospinal fluid (CSF) at 1 mg/kg without changing -APPs in rabbit and significantly decreased CSF A in AD patients.[4]
References:1. F. B. Vivino, I. Al-Hashimi, Z. Khan, F. G. LeVeque, P. L. Salisbury, 3rd, T. K. Tran-Johnson, C. C. Muscoplat, M. Trivedi, B. Goldlust and S. C. Gallagher, Arch Intern Med 1999, 159, 174-181. 2. M. Ono, E. Takamura, K. Shinozaki, T. Tsumura, T. Hamano, Y. Yagi and K. Tsubota, Am J Ophthalmol 2004, 138, 6-17. 3. K. Ono, T. Inagaki, T. Iida, R. Hosokawa and K. Inenaga, J Med Invest 2009, 56 Suppl, 375. 4. A. Fisher, Z. Pittel, R. Haring, N. Bar-Ner, M. Kliger-Spatz, N. Natan, I. Egozi, H. Sonego, I. Marcovitch and R. Brandeis, J Mol Neurosci 2003, 20, 349-356.

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