c-FMS inhibitor

Short Summary : C-FMS kinase inhibitor

Category : Tyrosine Kinase|c-FMS

Purity : 0.98

CAS Number : 885704-21-2

Formula : C23H30N6O

Molecular Weight : 406.52

SMILE : CC1CCN(CC1)C2=C(C=CC(=C2)N3CCN(CC3)C)NC(=O)C4=CC(=CN4)C#N

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : c-FMS inhibitor, 4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl) phenyl]-1H-pyrrole-2-carboxamide, is a novel FMS kinase inhibitors as anti-inflammatory agents with an IC50 value of 0.8 nM.[1] c-FMS inhibitor resulted in identification of a highly potent series of 2,4-disubstituted arylamides. It served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.[1] c-FMS inhibitors has a potential to form reactive metabolites which are transformed into a series with equivalent potency by incorporation of carbon-based replacement groups. Structure-based model provides the framework to efficiently effect this transformation and restore potencies to previous levels. This optimization removed a risk factor for potential idiosyncratic drug reactions.[2]References:Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8Structure-based optimization of a potent class of arylamide FMS inhibitors. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3632-7.

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