D-64131

Short Summary : Tubulin polymerization inhibitor

Category : Cell Cycle/Checkpoint|Microtubule/Tubulin

Purity : 0.98

CAS Number : 74588-78-6

Formula : C16H13NO2

Molecular Weight : 251.28

SMILE : COC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3

Solubility : Soluble in DMSO > 10 mM

Storage : Store at -20°C

Description : D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 M. [1]
The polymerization of bovine brain tubulin as well as binding of [3H] colchicine to biotinylated -tubulin was dose-dependently inhibited by D-64131. Many cancer cells display abnormal microtubule structures, such as fragmented mitotic spindles or multiple spindle poles after treatment with D-64131. Nuclear blebbing and abnormal nuclear structures typical for apoptotic cells are detectable in many cells treated with D-64131. In nude mice, D-64131 proved to be well tolerated and highly active against the human amelanoic melanoma MEXF 989 tumor xenograft. D-64131 treatment resulted in significant tumor growth inhibition during treatment. [1]
Reference:1. Beckers T, Reissmann T, Schmidt M et al. 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 2002 Jun 1;62(11):3113-9.

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