Dabigatran ethyl ester

Short Summary : Thrombin activity inhibitor

Category : Proteases|Thrombin

Purity : 0.98

CAS Number : 429658-95-7

Formula : C27H29N7O3

Molecular Weight : 499.56

SMILE : CCOC(CCN(C(C1=CC2=C(N(C)C(CNC3=CC=C(C(N)=N)C=C3)=N2)C=C1)=O)C4=CC=CC=N4)=O

Solubility : DMSO

Storage : Store at -20°C

Description : Dabigatran is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity. Dabigatran provides a stable anticoagulation effect without any need to perform periodical laboratory controls. Of note, there is a growing amount of clinical evidence which shows its safety and efficacy. For these reasons, Dabigatran may suppose a revolution in oral anticoagulation. Dabigatran etexilate was rapidly converted to Dabigatran, with peak plasma dabigatran concentrations being attained after approximately 1.5 h; the bioavailability of Dabigatran after p.o. administration of Dabigatran etexilate was 7.2%.

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