Eldecalcitol

Short Summary : Analog of 1,25-dihydroxyvitamin D3

Category : Vitamin D Related|VD/VDR

Purity : 0.98

CAS Number : 104121-92-8

Formula : C30H50O5

Molecular Weight : 490.72

SMILE : CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(C(C(C3=C)O)OCCCO)O)C

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : Osteoporosis is characterized by a reduction in bone mass with age, contributing to a loss in bone strength. Vitamin D is a crucial factor for the intestinal absorption of calcium to maintain bone strength. 1,25(OH)2D3 and its prodrugs alfacalcidol (ALF) and eldecalcitol are widely used in the treatment of Ca- and bone-related diseases including osteoporosis, hyperparathyroidism, osteomalacia, and renal osteodystrophy.In vitro: Compared with 1,25(OH)2D3, eldecalcitol has a higher affinity for serum DBP, binds more weakly to VDR, and shows lower potency in suppression of serum PTH. Moreover, the plasma half-life of eldecalcitol is longer than that of 1,25(OH)2D3, probably due to the higher affinity for DBP [1]. In vivo: In ovariectomized rat model of osteoporosis, eldecalcitol was found to have a greater activity than alfacalcidol in suppressing bone resorption as well as increasing bone mineral density (BMD) [2]. Clinical trial: Eldecalcitol is approved in Japan for the treatment of osteoporosis. Compared to a placebo treatment, treatment with eldecalcitol for 1 year significantly increased lumbar spine and total hip bone mineral density (BMD) and reduced bone turnover markers in a dose-dependent manner [3].Reference:[1] Noguchi Y, Kawate H, Nomura M, Takayanagi R. Eldecalcitol for the treatment of osteoporosis. Clin Interv Aging. 2013;8:1313-21. [2] Sakai S, Endo K, Takeda S, Mihara M, Shiraishi A. Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength. Bone. 2012 May;50(5):1054-63. [3] Shiraki M, Saito H, Matsumoto T. Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels. Curr Med Res Opin. 2012 Sep;28(9):1547-52.

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