Fluvastatin

Short Summary : HMGCR inhibitor

Category : Metabolism|HMG-CoA Reductase

Purity : 0.9866

CAS Number : 93957-54-1

Formula : C24H26FNO4

Molecular Weight : 411.47

SMILE : CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)O)O)O)C3=CC=C(C=C3)F

Solubility : >20.6mg/mL in DMSO

Storage : Store at -20°C

Description : Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin, HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

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