INCB 3284 dimesylate

Short Summary : HCCR2 antagonist

Category : GPCR/G protein|CCR2

Purity : 0.98

CAS Number : 887401-93-6

Formula : C28H39F3N4O10S2

Molecular Weight : 712.76

SMILE : COC1=NC=C(C2(O)CCC(N3CCC(NC(CNC(C4=CC(C(F)(F)F)=CC=C4)=O)=O)C3)CC2)C=C1.CS(=O)(O)=O.CS(=O)(O)=O

Solubility : Soluble in DMSO > 10 mM

Storage : Store at -20°C

Description : INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist. INCB 3284 exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). INCB 3284 also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μM).

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