Lck inhibitor 2

Short Summary : Tyrosine kinases inhibitor

Category : Tyrosine Kinase|Src

Purity : 0.98

CAS Number : 944795-06-6

Formula : C18H17N5O2

Molecular Weight : 335.36

SMILE : CC1=C(C=C(C=C1)O)NC2=NC(=NC=C2)NC3=CC=CC(=C3)C(=O)N

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : Description:
IC50 Value: 13 nM(Lck) [1]
Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK.27. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively [1].
Lck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM)[2].
in vitro: N/A
in vivo: N/A
Clinical trial: N/A

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