MBX-2982

Short Summary : GPR119 agonist,selective and orally-available

Category : GPCR/G protein|GPR119

Purity : 0.98

CAS Number : 1037792-44-1

Formula : C22H24N8OS

Molecular Weight : 448.54

SMILE : CCC1=CN=C(N=C1)N2CCC(CC2)C3=NC(=CS3)COC4=CC=C(C=C4)N5C=NN=N5

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally-active GPR119 agonist that functions through a unique dual mechanism of action. First, it acts directly on the beta cell to increase insulin secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health.

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