MC 976

Short Summary : Vitamin D3 derivative

Category : Vitamin D Related|VD/VDR

Purity : 0.98

CAS Number : 129831-99-8

Formula : C27H42O3

Molecular Weight : 414.62

SMILE : CC(CCC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description :
MC 969 is an analog of the calcemic drug 1-hydroxyvitamin D3 (1-OH-D3) whose carbons 25, 26, and 27 in the side chain are incorporated into a cyclopropane ring. MC 976 is the in vitro metabolite of MC 969.
In vitro: Metabolite of MC 976 was generated by incubation of MC 969 in an novel in vitro human hepatocyte cell model (Hep 3B) [1].
In vivo: MC 969 and other VD3 cyclopropane ring-analogs were previously found to possess potent calcemic effects in rat in vivo [2].
Clinical trial: Currently there is no clinical data available for MC 969 and its analogues .
References:[1] Strugnell S, Calverley MJ, Jones G. Metabolism of a cyclopropane-ring-containing analog of 1 alpha-hydroxyvitamin D3 in a hepatocyte cell model. Identification of 24-oxidized metabolites. Biochemical Pharmacology,1990; 40(2):333-341.[2] Jones G and DeLuca HF. High-performance liquid chromatography of vitamin D and its application to endocrinology. In: Monographs on Endocrinology, Vol. 30: High-performance liquid chromatography in endocrinology (Eds. Makin HLJ and Newton R), pp. 95-139. Springer, Berlin, 1988.

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