Necrostatin 2

Short Summary : In vitro necroptosis inhibitor

Category : Apoptosis|TNF-?

Purity : 0.98

CAS Number : 852391-19-6

Formula : C13H12ClN3O2

Molecular Weight : 277.71

SMILE : CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : Necrostatin 2 (Nec-2) is a novel and potent necroptosis inhibitor with EC50 of 50 nM. It is an analog of necrostatin 1 (nec-1). Necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented. Nec-2 is efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. There is limited record for Nec-2, but some reports are related with other necrostatins. Nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP1 in vitro.Reference:[1]. Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40.

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