PAP-1

Short Summary : Kv1.3 inhibitor

Category : Membrane Transporter/Ion Channel|Kv1.3

Purity : 0.98

CAS Number : 870653-45-5

Formula : C21H18O5

Molecular Weight : 350.37

SMILE : C1=CC=C(C=C1)OCCCCOC2=C3C=CC(=O)OC3=CC4=C2C=CO4

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : PAP-1 is selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels. In treatment of multiple sclerosis

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