Z-Ligustilide

Short Summary : facilitates blood circulation and attenuates inflammatory pain behavior

Category : Nature Products

Purity : 0.9887

CAS Number : 4431-01-0

Formula : C12H14O2

Molecular Weight :

Molecular Weight : 190.23

SMILE : CCCC=C1C2=C(C=CCC2)C(=O)O1

Solubility : >16.5mg/mL in DMSO

Storage : Store at -20°C

Description : IC50: 2.27 and 4.78 M against L1210 and K562 cell lines Z-Ligustilide, isolated and purified from the essential oil of A. sinensis. Z-Ligustilide has been reported to facilitate blood circulation and attenuate inflammatory pain behavior.In vitro: Previous results showed pretreatment with Z-Ligustilide (LIG) improved cell viability significantly. The apoptosis rate in glutamate-induced PC12 cells decreased in the presence of LIG. Western blot results indicated that LIG could decrease the release of Cyt C from mitochondria, up-regulate Bcl-2/Bax ratio and down-regulate Caspase-3 protein expression, resulting in protecting PC12 cells from apoptosis [1]. In vivo: In ovariectomized (OVX) osteopenic rats, the anti-inflammatory potential of LIG was determined by ELISA. LIG was found to be able to inhibit OVX-induced up-regulation of NF-B activation and the production of TNF-, iNOS, IL-1, ICAM-1 and COX-2 significantly. In addition, LIG could suppress MDA and PMN infiltration. The significant anti-inflammatory effect of Z-Ligustilide in experimental OVX osteopenic rats clearly demonstrated that there might be an inflammatory component in the etiology of osteoporosis [2]. Clinical trial: N/AReferences:[1] Wu Q,Wang N,Wang Y,Wang GY,Piao XX. rotective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao.2015 Feb;50(2):162-8.[2] Ma Z,Bai L. The anti-inflammatory effect of Z-Ligustilide in experimental ovariectomized osteopenic rats. Inflammation.2012 Dec;35(6):1793-7.

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