T6167923

T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM; specifically inhibits TIR domain-mediated dimerization of full-length MyD88 as well as the recombinant TIR domain protein; dose-dependent in vivo therapeutic efficacy against SEB intoxication.

Target : MyD88

CAS Number : 1090528-71-4

Formula Weight : 458.389

Molecular Formula : C17H20BrN3O3S2

Purity : >98% (HPLC)

Storage : (-20?)

Shipping Conditions : With Ice Pack

Stability : ? 2 years

Research use only, not for human use.