(24R)-MC 976

Short Summary : Vitamin D3 derivative

Category : Vitamin D Related|VD/VDR

Purity : 0.98

CAS Number : 112828-09-8

Formula : C27H42O3

Molecular Weight : 414.62

SMILE : CC(CCC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : MC 969 is an analog of the calcemic drug 1α-hydroxyvitamin D3 (1α-OH-D3). Metabolites of MC 969 were generated in an in vitro human hepatocyte cell model (Hep 3B), leading to identify the 24 (R) alcohols metabolite of MC 969, (24R)-MC 976. In vitro: Metabolic study of MC 969 were generated in an in vitro human hepatocyte cell model, Hep 3B. It was found that unequivocal identification of the 24-keto- and the two epimeric 24-alcohol metabolites (24 (R,S) alcohols of MC 969) was provided. In the competition studies, MC 969 was able to inhibit 25-hydroxylation of tritiated vitamin D3 more effectively than lα-OH-D3 itself, indicating that the vitamin D3-25-hydroxylase may be responsible for generation of one or more of the metabolites observed [1].In vivo: No animal in-vivo data available currently. Clinical trial: (24R)-MC 976 is currently in the preclinical developlent stage and no clinical data are available.Reference:[1] Strugnell S, Calverley MJ, Jones G. Metabolism of a cyclopropane-ring-containing analog of 1 alpha-hydroxyvitamin D3 in a hepatocyte cell model. Identification of 24-oxidized metabolites. Biochem Pharmacol. 1990;40(2):333-41.

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