Amyloid β-Protein (1-15)

Short Summary : Principal component of amyloid

Category : Neuroscience|Amyloid β

Purity : 0.98

CAS Number : 183745-81-5

Formula : C78H107N25O27

Molecular Weight : 1826.86

SMILE : CC(C)C(C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CNC=N2)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)N

Solubility : >182.6mg/mL in DMSO

Storage : Store at -20°C

Description : Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Research found that amyloid beta-protein circulates in human blood and in cerebrospinal fluid and is deposited into plaques found in the brains of patients with Alzheimer’s disease (AD). The aggregation of the beta-amyloid protein into dense plaques on the exterior of brain cells results in destroys of the synapses and conduction of nerve impulses.
Ref:
1. Sisodia SS, Price DL. Role of the beta-amyloid protein in Alzheimer’s disease. FASEB J. 1995 Mar; 9(5): 366-70.

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