Andrographolide

Short Summary : NF-?B signaling Inhibitor

Category : Immunology/Inflammation|I?B/IKK

Purity : 0.9967

CAS Number : 5508-58-7

Formula : C20H30O5

Molecular Weight :

Molecular Weight : 350.44

SMILE : CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O

Solubility : >16mg/mL in DMSO

Storage : Store at -20°C

Description : IC50: 11.0 0.28 g/ml for -glucosidase; 11.3 0.29 g/ml for -amylase Andrographolide is an irreversible antagonist of NF-B. The nuclear factor NF-B pathway has been considered as a prototypical proinflammatory signaling pathway, based on the role of NF-B in the expression of proinflammatory genes including chemokines, cytokines and adhesion molecules.In vitro: Andrographolide was found to suppress the expression of inducible nitric oxide synthase in a concentration-dependent manner. In the andrographolide-treated group, a reduction of Akt, c-Jun N-terminal kinase and p65 phosphorylation was observed. Andrographolide also caused a decrease in Bcl-2/NF-b expression and a dose-dependent increase in the expression of Cleaved-Caspase3/Bax protein [1]. In vivo: Rats were dosed with andrographolide intragastrically for 5 consecutive days in a hepatoprotection study. Results indicated that andrographolide could up-regulate glutamate cysteine ligase catalytic and modifier subunits, heme oxygenase-1, superoxide dismutase-1, glutathione S-transferase protein and mRNA expression in the heart, liver, and kidney [2]. Clinical trial: N/AReferences:[1] Wang ZM,Kang YH,Yang X,Wang JF,Zhang Q,Yang BX,Zhao KL,Xu LP,Yang LP,Ma JX,Huang GH,Cai J,Sun XC. Andrographolide radiosensitizes human esophageal cancer cell line ECA109 to radiation in vitro. Dis Esophagus.2016 Jan;29(1):54-61. [2] Chen HW,Huang CS,Li CC,Lin AH,Huang YJ,Wang TS,Yao HT,Lii CK. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. Toxicol Appl Pharmacol.2014 Oct 1;280(1):1-9.

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