Astragaloside II

Short Summary : monomer of Astragalus saponin

Category : Nature Products

Purity : 0.98

CAS Number : 84676-89-1

Formula : C43H70O15

Molecular Weight :

Molecular Weight : 827.02

SMILE : N/A

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : Astragaloside II (AST II) is a monomer of Astragalussaponin. In vitro: Astragaloside II increased the CD45-mediated of pNPP/OMFP hydrolysis in a concentration-dependent manner. The EC50value was 9.23g/mL.10 and 30 nmol/L astragaloside II treatment significantly enhanced the proliferation of primary splenocytes induced by ConA, alloantigen or anti-CD3. 30 nmol/L astragaloside II treatment significantly increased IL-2 and IFN-secretion and upregulated the mRNA levels of IFN-and T-bet in primary splenocytes. Inprimary CD4+T cells,astragaloside IIpromoted CD25 and CD69 expression upon TCR stimulation. Furthermore, treatment with 100 nmol/L astragaloside II promoted CD45-mediated dephosphorylation of LCK (Tyr505) in primary T cells [1]. Astragaloside IIshowed a significant induction of cell proliferation, differentiation and mineralization in theprimaryosteoblasts [2]. In 5-fluorouracil-resistant human hepatic cancer cells Bel-7402/FU, 0.08mg/ml Astragaloside II increased the cytotoxicity of 5-fluorouracil [3].In vivo: In CTX-inducedimmune-compromised mice, oral administration of astragaloside II (50 mg/kg) promoted the proliferation of splenic T cells while showed no effects on the proliferation. Astragaloside II also promoted the production of IFN-and IL-2 [1]. References:Wan C, Gao L, Hou L, et al. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity[J]. ActaPharmacologicaSinica, 2013, 34(4): 522-530.Kong X H, Niu Y B, Song X M, et al. Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways[J]. International journal of molecular medicine, 2012, 29(6): 1090-1098.Huang C, Xu D, Xia Q, et al. Reversal of Pglycoproteinmediated multidrug resistance of human hepatic cancer cells by AstragalosideII[J]. Journal of Pharmacy and Pharmacology, 2012, 64(12): 1741-1750.

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