BAY 61-3606 dihydrochloride

Short Summary : Syk tyrosine kinase inhibitor

Category : Tyrosine Kinase|Spleen Tyrosine Kinase (Syk)

Purity : 0.98

CAS Number : 648903-57-5

Formula : C20H20Cl2N6O3

Molecular Weight : 463.32

SMILE : COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl.Cl

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : BAY 61-3606 is Syk Inhibitor IV. BAY 61-3606 (BAY 61-3606) is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. BAY 61-3606 has been shown to inhibit Syk-mediated cellular functions such as inhibition of high glucose-tyrosine phosphorylation of I kappa B α and p65 nuclear translocation. In mast cells BAY 61-3606 has inhibited cytokine synthesis, lipid mediation and degranulation. In addition, monocyte and eosinophil activation by B cells and Fc receptors were suppressed by BAY 61-3606.

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