Bitopertin (R enantiomer)

Short Summary : Glycine reuptake inhibitor

Category : Membrane Transporter/Ion Channel|GlyT1

Purity : 0.98

CAS Number : 845614-12-2

Formula : C21H20F7N3O4S

Molecular Weight : 543.46

SMILE : CC(C(F)(F)F)OC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N2CCN(CC2)C3=C(C=C(C=N3)C(F)(F)F)F

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : R enantiomer of RG1678. RG1678 (Bitopertin) is a potent and noncompetitive glycine reuptake inhibitor (GlyT1). Recent Phase II data shows that RG1678 is effective in reducing the negative symptoms when given in combination with second generation antipsychotics. RG1678 is currently in Phase III trials for the treatment of the negative symptoms of schizophrenia.

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