CC-401 hydrochloride

Short Summary : JNK inhibitor

Category : MAPK Signaling|JNK

Purity : 0.98

CAS Number : 1438391-30-0

Formula : C22H25ClN6O

Molecular Weight : 424.93

SMILE : C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5.Cl

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation.

Download datasheet