CPA inhibitor

Short Summary : Potent carboxypeptidase A (CPA) inhibitor

Category : Others|CPA

Purity : 0.98

CAS Number : 223532-02-3

Formula : C18H19NO4

Molecular Weight : 313.36

SMILE : C1=CC=C(C=C1)CC(CN(C(=O)CC2=CC=CC=C2)O)C(=O)O

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : CPA inhibitor (carboxypeptidase inhibitor) is a potent inhibitor of EGFR [1].EGFR (epidermal growth factor receptor) is a member of ErbB family of receptors and binds to the members of EGF-family. It has been reported that EGFR aberrant expression is correlated with cancer, inflammatory disease, monogenic disease and so on [1, 2].When tested with human pancreatic adenocarcinoma cell lines Capan-1, CPA inhibitor treatment significantly inhibited cells growth at the concentration more than 10 μg/ml and pre-treatment markedly inhibited cell proliferation rate [1]. In A431 and MDA-MB-453 cell lines, pre-treated with CPA inhibitor markedly suppressed EGFR expression level [2].In nude mouse model with Capan-1 cells subcutaneous xenograft, administration of CPA inhibitor significantly reduced solid tumor growth without side effects [1].References: [1].Blanco-Aparicio, C., et al., Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth. J Biol Chem, 1998. 273(20): p. 12370-7.[2].Sitja-Arnau, M., et al., Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker. Cancer Lett, 2005. 226(2): p. 169-84.

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