Curcumin

Short Summary : Tyrosinase inhibitor

Category : Immunology/Inflammation|KEAP1-Nrf2

Purity : 0.9616

CAS Number : 458-37-7

Formula : C21H20O6

Molecular Weight : 368.38

SMILE : COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

Solubility : >36.8mg/mL in DMSO

Storage : Store at -20°C

Description : Curcumin is an inhibitor of tyrosinase with IC50 value of 47uM [1]. Curcumin is a natural compound with potency of anticancer. It is currently under clinical investigation for cancer chemoprevention. There is a variety of biochemical mechanisms of this anticancer function. The targets of Curcumin are involved in signaling pathways include transcription factors, growth factors,inflammatory cytokines, receptors, and enzymes. Phase I trials have tested the toxicity and tolerability of Curcumin and found that Curcumin has no toxicities at doses up to 12 g/day. However, the bioavailability of Curcumin is quite poor. It is about ~1% after oral administration in phase I/II clinical trials and this hinders Curcumins use in the clinic [2].It is also reported that Curcumin reduces the generation of amloid beta (A 40 and A42) in SH-SY5Y neuroblastoma cells. It also down-regulates the expression of PS1 and GSK-3 in cells. All these cause the inhibition of A formation and make Curcumin to be a potent therapeutic agent in AD [3].References:[1] Sachiko Shirota, Kouji Miyazaki, Ritsuo Aiyama, Minoru Ichioka and Teruo Yokokura. Tyrosinase inhibitors from crude drugs. Biol. Pharm. Bull. 1994, 17 (2): 266-269.[2] Wungki Park, A.R.M Ruhul Amin, Zhuo Georgia Chen, and Dong M. Shin. New perspectives of curcumin in cancer prevention. Cancer Prev Res (Phila). 2013, 6(5): 387C400.[3] Zhang Xiong, Zhang Hongmei, SiLu, LiYu. Curcumin mediates presenilin-1 activity to reduce -amyloid production in a model of Alzheimers disease. Pharmacological Reports. 2013, 63: 1101-1108.

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