Doxazosin Mesylate

Short Summary : α1-adrenergic receptor antagonist

Category : GPCR/G protein|Adrenergic Receptor

Purity : 0.98

CAS Number : 77883-43-3

Formula : C23H25N5O5.CH4O3S

Molecular Weight : 547.58

SMILE : COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.CS(=O)(=O)O

Solubility : Soluble in DMSO > 10 mM

Storage : Store at -20°C

Description : Doxazosin Mesylate is a selective, long-lasting antagonist of 1-adrenergic receptor [1].Doxazosin Mesylate has been reported to potentiate contraction response to 5-HT in a dose-dependent manner [1]. Doxazosin significantly reduced alcohol drinking and increased water intake in adult male P rats [2]. Studies has indicated that doxazosin could inhibit TNF- expression in LPS-induced systemic inflammation model as well as reduce the MCP-1 production in LPS-induced pulmonary inflammation model. Additionally, Doxazosin decreased thickness of footpad in the delayed-type hypersensitivity mice model. Doxazosin had been reported to slightly reduce MCP-1 level in the peritoneal cavity of mice induced by thioglycollate [3].References:[1] Zhao Y1, Cao XB, Ren LM. Doxazosin selectively potentiates contraction to serotonin via 5-HT A receptors in longitudinal muscle strips of the rabbit gastric body. Can J Physiol Pharmacol. 2014 Mar;92(3):197-204. [2] O’Neil ML1, Beckwith LE, Kincaid CL, Rasmussen DD. The 1-adrenergic receptor antagonist, doxazosin, reduces alcohol drinking in alcohol-preferring (P) Rats. Alcohol Clin Exp Res. 2013 Feb;37(2):202-12.[3] Tung D1, Ciallella J, Cheung PH, Saha S. Novel anti-inflammatory effects of doxazosin in rodent models of inflammation. Pharmacology. 2013;91(1-2):29-34.

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