Fagomine

Short Summary : Anti-diabetic

Category : Others|Others

Purity : 0.98

CAS Number : 53185-12-9

Formula : C6H13NO3

Molecular Weight : 147.18

SMILE : C1CNC(C(C1O)O)CO

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : Fagomine is a good inhibitor of various Glycosidases, including rat intestinal surcase and bovine α-Fucosidase with IC50 of 90μM and 140 μM, respectively. [1]Fagomine has been shown to have some activity against mammalian gut R -glucosidase and β-galactosidase, Moreover, fagomine was also found to have a potent antihyperglycemic effect in streptozocin-induced diabetic mice and to potentiate markedly immunoreactive insulin release. [2]Fagomine inhibitory activity was tested against different enzymes with IC50 of 90μM and 140 μM for rat intestinal surcase and bovine α-Fucosidase, respectively. Furthermore, the IC50 values for α-glucosidase in rice and yeast, along with rat intestinal maltase and isomaltase were also determined and the results were 320 880 820 and 460μM, respectively. The activities of rice R -glucosidase and rat digestive glycosidases were determined using the appropriate disaccharides as substrates at the optimum pH of each enzyme. The released D-glucose was determined colorimetrically using the glucose B-test. Other glycosidase activities were determined using an appropriate p-nitrophenyl glycoside as a substrate at the optimum pH of each enzyme. [1]D-Fagomine lowered postprandial glycaemia in SD rats after the intake of sucrose and starch. D-Fagomine effectively regulated postprandial glycaemia in a dose-dependent manner, which led to a reduction in AUC at 120 min between 17 % and 43 % after the intake of 1 g sucrose/kg body weight. D-Fagomine effectively modulates the glucose level in blood in a dose-dependent manner after the ingestion of sucrose or starch, probably by delaying saccharide hydrolysis by brush-border glycosidases. [3]References:[1]. Goujon J Y, Gueyrard D, Compain P, et al. General synthesis and biological evaluation of α-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-α-C-glycosides)[J]. Bioorganic & medicinal chemistry, 2005, 13(6): 2313-2324.[2]. Kato A, Asano N, Kizu H, et al. Fagomine isomers and glycosides from Xanthocercis zambesiaca[J]. Journal of natural products, 1997, 60(3): 312-314.[3]. Gómez L, Molinar-Toribio E, Calvo-Torras M á, et al. d-Fagomine lowers postprandial blood glucose and modulates bacterial adhesion[J]. British Journal of Nutrition, 2011, 1(1): 1-8.

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