Fulvestrant (ICI 182,780)

Short Summary : Estrogen receptor antagonist,high affinity

Category : Endocrinology and Hormones|Estrogen/progestogen Receptor

Purity : 0.9809

CAS Number : 129453-61-8

Formula : C32H47F5O3S

Molecular Weight : 606.77

SMILE : CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F

Solubility : >30.3mg/mL in DMSO

Storage : Store at -20°C

Description : Fulvestran is a newer type of estrogen receptor (ER) antagonist with IC50 value of 9.4nM [1]. Fulvestrant treatment caused a significant decrease in MDM2 protein expression in human breast cancer cell lines MCF7 and T47D, and that the reduction of MDM2 correlated with the decrease in ER expression [1]. Fulvestrant enhances the sensitivity of human breast cancer cells to chemotherapeutic drugs. CompuSyn analyses showed that combined use of doxorubicin, paclitaxel or etoposide with fulvestrant resulted in different degrees of synergism in MCF7 and T47D cell lines tested. Besides, Combination of fulvestrant and chemotherapeutic drugs induces altered cell cycle distribution, apoptosis, and senescence [1].References:[1] Dolfi SC1, J ger AV2, Medina DJ1, Haffty BG3, Yang JM4, Hirshfield KM5.Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs. Cancer Lett. 2014 Apr 18. pii: S0304-3835(14)00215-8.

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