GAP-134

Short Summary : Gap junction modifier

Category : Neuroscience|Gap Junction

Purity : 0.98

CAS Number : 943134-39-2

Formula : C14H17N3O4

Molecular Weight : 291.3

SMILE : O=C(O)C1N(C(CN)=O)CC(NC(C2=CC=CC=C2)=O)C1

Solubility : DMSO

Storage : Store at -20°C

Description : Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). GAP-134 (Danegaptide), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. Gap junction modifier GAP-134, showed consistent efficacy on measures of conduction and AF/AFL inducibility in the canine sterile pericarditis model. GAP-134 is a pharmalogical agent with a favorable clinical safety profile and potential antiarrhythmic efficacy, as already confirmed in phase I clinical trials.

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