GAP-134 Hydrochloride

Short Summary : Gap-junction modifier,potent and selective

Category : Neuroscience|Gap Junction

Purity : 0.98

CAS Number : 943133-81-1

Formula : C14H18ClN3O4

Molecular Weight : 327.76

SMILE : C1C(CN(C1C(=O)O)C(=O)CN)NC(=O)C2=CC=CC=C2.Cl

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). GAP-134 (Danegaptide), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. Gap junction modifier GAP-134, showed consistent efficacy on measures of conduction and AF/AFL inducibility in the canine sterile pericarditis model. GAP-134 is a pharmalogical agent with a favorable clinical safety profile and potential antiarrhythmic efficacy, as already confirmed in phase I clinical trials.

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