GW843682X

Short Summary : PLK1/PLK3 inhibitor,potent and selective

Category : Cell Cycle/Checkpoint|PLK

Purity : 0.98

CAS Number : 660868-91-7

Formula : C22H18F3N3O4S

Molecular Weight : 477.46

SMILE : COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC

Solubility : Soluble in DMSO > 10 mM

Storage : Store at -20°C

Description : GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). GW843682X displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. GW843682X inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts.

Download datasheet