IFN-gamma, murine recombinant

Short Summary : IFN-?, proinflammatory cytokine, expressed in E.Coli, suitable for cell culture.

Category : Cytokines|Interferon

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Storage : Store at -20°C

Description : Interferon-gamma (IFN-?) is a prototype proinflammatory cytokine that is mainly produced by activated T, B and NK cells. IFN-? exists immunoregulatory activities, anti-viral activities, anti-proliferative and proinflammatory activities. IFN-? can also upregulate MHC class I and II antigen expression by antigen-presenting cells. IFN-? plays a key role in host defense by promoting the development and activation of Th1 cells, up-regulation of antigen presentation molecules, chemoattraction and activation of monocytes and macrophages and immunoglobulin class switching in B cells. In addition, IFN-? functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation.
Mature mouse IFN-? exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits. Recombinant murine IFN-? is a 15.6 kDa protein containing 134 amino acid residues.

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