IOX 1

Short Summary : histone demethylase JMJD inhibitor

Category : Chromatin/Epigenetics|Histone Demethylases

Purity : 0.98

CAS Number : 5852-78-8

Formula : C10H7NO3

Molecular Weight :

Molecular Weight : 189.17

SMILE : OC1=C2N=CC=CC2=C(C(O)=O)C=C1

Solubility : >5.75mg/mL in DMSO

Storage : Store at -20°C

Description : IOX 1 (5-carboxy-8HQ) is an inhibitor of histone demethylase JMJD with IC50 values of 0.2 M for JMJD2E [1]. The Jumonji domain (JMJD) is a histone demethylase and acts as a transcriptional repressor. IOX 1 is a histone demethylase JMJD inhibitor. In the FDH-coupled assay, IOX 1 inhibited JMJD2E with IC50 value of 0.2 M. In MALDI-TOF MS assay, IOX 1 inhibited JMJD2E, JMJD2A, FIH and PHD2 with IC50 values of 2.4, 1.7, 20.5 and 14.3 M, respectively. In HeLa cells, IOX 1 increased H3K9me3 fluorescence intensity, suggesting that IOX 1 inhibited H3K9me3 demethylation induced by JMJD2A with IC50 value of 86.5 M. Also, IOX 1 exhibited cytotoxicity with IC50 value of 291.6 M [1]. Reference:[1]. King ON, Li XS, Sakurai M, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One, 2010, 5(11): e15535.

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