MK-8033

Short Summary : C-MET inhibitor

Category : Tyrosine Kinase|c-MET

Purity : 0.98

CAS Number : 1001917-37-8

Formula : C25H21N5O3S

Molecular Weight : 471.53

SMILE : CN1C=C(C2=CN=C3C=CC4=C(C(C3=C2)=O)C=C(CS(=O)(NCC5=CC=CC=N5)=O)C=C4)C=N1

Solubility : DMSO

Storage : Store at -20°C

Description : MK-8033 is a c-MET inhibitor in clinical trials. MK8033 is a selective small-molecule inhibitor, ATP competitive. Phase I investigation of the cMet inhibitor MK-8033 is ongoing. Plans include a trial of this agent in refractory colorectal cancer, with pre- and post-treatment biopsies to evaluate for relevant molecular signatures.

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