Morin hydrate

Short Summary : antioxidant

Category : Nature Products

Purity : 0.98

CAS Number : 6202-27-3

Formula : C15H10O7.H2O

Molecular Weight :

Molecular Weight : 320.25

SMILE : OC1=C(C(C(O)=C2)=CC=C2O)OC3=CC(O)=CC(O)=C3C1=O.O

Solubility : Soluble in DMSO > 10 mM

Storage : Store at -20°C

Description : Morin hydrate is a plant flavonoid extracted from yellow Brazil wood with anti-oxidant properties. Previous studies have shown that morin hydrate could protect cells against oxygen radical damage. In vitro: Morin hydrate at 75-100 M protected against the oxidation of low density lipoprotein (LDL) induced by free radicals [1]. Morin hydrate at 100 M concentration effectively inhibited Cu2+-induced oxidation of human LDL [2]. In cultured rat glomerular mesangial cells attacked by oxyradicals, the survival time of the cells was doubled with using morin hydrate [3]. 0.25 C 2.0 mM morin prolonged the survival of rat hepatocytes against free radical damage triggered by xanthine oxidase-hypoxanthine [4]. Morin hydrate could inhibit the amyloid formation by islet amyloid polypeptide and disaggregated amyloid fibers [5].In vivo: In a 80 min ischemia rat model, treatment of morin at 2.5, 5.0 and 10 mol/Kg reduced liver necrosis by 51.48 9.94%, 66.55 2.18%, and 79.37 11.03%, respectively [3].References:Wu T W, Fung K P, Wu J, et al. Morin hydrate inhibits azo-initiator induced oxidation of human low density lipoprotein[J]. Life sciences, 1995, 58(2): PL17-PL22.Wu T W, Fung K P, Yang C C, et al. Antioxidation of human low density lipoprotein by horin hydrate[J]. Life sciences, 1995, 57(3): PL51-PL56.Zeng L H, Fung K P, Wu T W. Morin hydrate protects cultured rat glomerular mesangial cells against oxyradical damage[J]. Life sciences, 1994, 55(18): PL351-PL357.Wu T W, Zeng L H, Wu J, et al. Morin hydrate is a plant-derived and antioxidant-based hepatoprotector[J]. Life sciences, 1993, 53(13): PL213-PL218.Noor H, Cao P, Raleigh D P. Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers[J]. Protein Science, 2012, 21(3): 373-382.

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