Nifuratel

Short Summary : Antibacterial, antifungal, and antiprotozoal compound

Category : Microbiology & Virology|Antibiotic

Purity : 0.98

CAS Number : 4936-47-4

Formula : C10H11N3O5S

Molecular Weight : 285.28

SMILE : CSCC1CN(C(=O)O1)N=CC2=CC=C(O2)[N+](=O)[O-]

Solubility : Soluble in DMSO

Storage : Store at -20°C

Description : Description:
IC50 Value: 0.125-1 ?g/mL(MIC, A. vaginae) [1]
Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp.
in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 ?g/mL; it is active against G. vaginalis and does not affect lactobacilli [1].
in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2].
Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3].
Clinical trial: N/A

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