NPS-2143 hydrochloride

A potent, selective and orally active CaSR antagonist with IC50 of 43 nM; does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors; stimulates parathyroid hormone (PTH ) secretion from bovine parathyroid cells in vitro (EC50=39 nM) and increases plasma PTH levels in vivo; also inhibits lipopolysaccharide-induced pulmonary inflammation.OsteoporosisDiscontinued

Target : CaSR

CAS Number : 324523-20-8

Formula Weight : 445.3814

Molecular Formula : C24H26Cl2N2O2

Purity : >98% (HPLC)

Storage : (-20?)

Shipping Conditions : With Ice Pack

Stability : ? 2 years

Research use only, not for human use.