PF-431396

Short Summary : Pyk2 and FAK inhibitor

Category : Tyrosine Kinase|Pyk2

Purity : 0.9811

CAS Number : 717906-29-1

Formula : C22H21F3N6O3S

Molecular Weight :

Molecular Weight : 506.5

SMILE : CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C

Solubility : >18.1mg/mL in DMSO

Storage : Store at -20°C

Description : PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treating A20 cells.

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